SEP-363856 hydrochloride

CAS No. 1310422-41-3

SEP-363856 hydrochloride ( SEP-856 hydrochloride )

Catalog No. M22443 CAS No. 1310422-41-3

SEP-363856 hydrochloride is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to treatment of schizophrenia. SEP-856 (10μM) specifically inhibits α2A, α2B, D2, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C and 5-HT7> 50% receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 224 Get Quote
10MG 374 Get Quote
25MG 623 Get Quote
50MG 887 Get Quote
100MG 1197 Get Quote
500MG 2394 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    SEP-363856 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    SEP-363856 hydrochloride is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to treatment of schizophrenia. SEP-856 (10μM) specifically inhibits α2A, α2B, D2, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C and 5-HT7> 50% receptor.
  • Description
    SEP-363856 hydrochloride is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to treatment of schizophrenia. SEP-856 (10μM) specifically inhibits α2A, α2B, D2, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C and 5-HT7> 50% receptor.SEP-856 (0.3, 1 and 10 mg/kg, i.p.) is CNS active. SEP-856 exhibits a behavioral signature similar to known antipsychotic drugs.PCP-induced hyperactivitysignificantly reduced by SEP-856 (0.3, 1 and 10 mg/kg, orally once) . Oral SEP-856 administration (1, 3 and 10 mg/kg) produces a dosedependent decrease in REM sleep, increase in latency to REM sleep and increase in cumulative wake (W) time.
  • Synonyms
    SEP-856 hydrochloride
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT1A Receptor;5-HT1B Receptor;5-HT1D Receptor;5-HT2A Receptor;5-HT2C Receptor;5-HT7 Receptor;TAAR1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1310422-41-3
  • Formula Weight
    219.73
  • Molecular Formula
    C9H14ClNOS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:62.5 mg/mL (284.44 mM; Need ultrasonic)
  • SMILES
    Cl.CNC[C@@H]1OCCc2ccsc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dedic N, et al. SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D2 Receptor Mechanism of Action. J Pharmacol Exp Ther. 2019 Oct;371(1):1-14.
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